http://www.quora.com/Would-does-bluetooth-work-on-the-international-space-station

You must be very careful about the fluid dynamics of systems, in terms of both heat and fluids present. for example, you cant just put a heatsink on a thing, because without gravity, heat wont rise or dissipate well at all. Also, just like water, CO2 will form bubbles, so if you need airflow in a system there basically cant be anything passive. Lastly, realize that mixing fluids doesnt really work -- there are entire development teams dedicated to figuring out how to mix stuff in microgravity. 

What is it that you're designing for space?

I don't have anything specific that I'm designing for space, but I read up it all the time and wonder if I could do better than some of the failures. Like the Rosetta mission to the comet, the Philae lander failed to attach 2/3 of its landing grapples and led me to research the design and think about improvements. I would like to put some hardware in space, but there's not much that hasn't been done at this point. Maybe an asteroid sample return mission? Or a moon ice collector? Even an FPGA in LEO to test methods of radiation hardened computing, Idk yet

this looked cool                    http://ntrs.nasa.gov/archive/nasa/casi.ntrs.nasa.gov/19930081080.pdf

there's radiation hardening and electromagnetic interference for starters, mainly shielding to worry about. I'm mostly interested in the materials - like for example space suits use MLI and so do a lot of spacecraft. The life support systems are pretty fascinating too. If you haven't watched chris hadfields videos yet checkem out.

If you haven't already found it, http://ntrs.nasa.gov/ may have some of what you are looking for. It's expansive, so searching through it cab be time consuming. A hint when looking for articles behind pay walls when the article or paper is by a NASA employee or contractor, the paper usually is also available on NTRS.

thanks for that link

I too am interested in this topic, particularly how it relates to printed circuit board design, like specific design rule requirements for space.

I spent some time getting to know the subject, and it seems that it comes down to the area of interplanetary space you're going to be operating in. Once deployed, need to watch out for occasionally violent space weather. NASA's initial solution was a ton of shielding (very heavy payload), in order to prevent occasional charged particles from damaging parts of integrated circuits, but eventually they settled with a highly redundant circuitry (much less heavy payload) -- they achieve it by using FPGAs to ensure that if one IC block is damaged by a stray particle then another identical block  (on the same FPGA chip) will kick in and your device will continue to function as if nothing happened. Neat huh?

Valuable info man, thanks ! Once you got the info it all looks so .... logical and straightforward ;) I guess only the part with the FPGA though :D