LiR2450 Battery

LiR2450 is a typical label for rechargeable 2450 batteries. Depending on the exact chemistry used, the LiR2450 battery typically features nominal voltages of 3.0, 3.2, 3.6, and 3.7 volts.

CR2450 Battery
Lithium 3.0V CR2450 battery is a non-rechargeable button/coin cell battery commonly used in watches, computer motherboards, medical devices, LED flashlights, toys, remote controls, car remote keys, security systems, wearable electronics, etc.

Differences between LiR2450 vs CR2450 
The main differences between CR2450 and LiR2450 batteries in the voltage, capacity, and of course, rechargeable feature.

Voltage difference - due to the voltage difference of ~0.6-0.7 volts, not all devices powered by the CR2450 battery will operate properly when powered by the LiR2450 battery. Actually, this voltage difference may even damage some more sensitive units.

Thus, unless the Owner's Guide of the device you have lists 3.6-3.7V LiR2450 batteries as supported battery type, do NOT replace CR2450 battery with LiR2450 battery.

Capacity difference - CR2450 battery features a much larger capacity than the LiR2450 battery. But, the LiR2450 battery may be recharged up to 500-1000 times, which is a lot.

Note: When charging LiR2450 batteries, be sure to use battery chargers specifically intended for such batteries.

Also, LiR2450 batteries feature a much larger self-discharge rate than CR2450 batteries, and is usually 10-30% per year, sometimes even more.

LiR2450 vs CR2450 Interchangeability
LiR2450 is a typical label for rechargeable 2450 batteries. Depending on the exact chemistry used, the LiR2450 battery typically features nominal voltages of 3.0, 3.2, 3.6, and 3.7 volts.

3.0V rechargeable LiR2450 batteries can be used as a direct replacement for CR2450 batteries since they feature the same (similar) output voltage that never exceeds 3.0 volts and pose no threat for sensitive electronics.

If you want to know more about LiR2450 vs CR2450, you can read its datasheet.