Identify on your RPi the six pins (1 to 6 according to RPi documentation) illustrated on the following picture (pins are the same on RPi ZW, RPi 2, 3 & 4):

Connect your breakout board on these pins according to the following picture (breakout board should be ABOVE the Raspberry Pi board). !!!Beware connecting the breakout board incorrectly WILL BREAK your board!!!

If you don't have an already ready to use Raspberry PI, you can follow the installation  instructions from the official website. Once installed, you have to enable I2C port in Linux kernel using the raspi-config command (5 Interfacing Options -> P5 I2C):

sudo raspi-config
sudo reboot

Use apt to install the packages required to compile the NXP Plug & Trust Middleware

sudo apt update
sudo apt-get install python cmake cmake-curses-gui cmake-qt-gui libssl-dev

Download the NXP's Plug & Trust MW from SE050 web page. You will need a user account. If you don't want download a proprietary piece of code, you can also base your developments on the open source library published by NXP on its Github page. Place the downloaded zip package in "/home/pi" folder for example and type:

cd /home/pi
unzip SE050-PLUG-TRUST-MW.zip -d se050_mw

Enter the following command lines: 

cd /home/pi/se050_mw/simw-top/scripts/
sudo python create_cmake_projects.py
cd /home/pi/se050_mw/simw-top_build/raspbian_native_se050_t1oi2c/
cmake --build .
sudo make install
sudo ldconfig /usr/local/lib

Type the two following commands:

cd /home/pi/se050_mw/simw-top_build/raspbian_native_se050_t1oi2c/
./se05x_Minimal

If everything is OK, you should see an output which looks like :

Congratulations ;-)