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Ibupromt

A project log for Sense-Aid

Electronic band-aid for monitoring fever and dispensing an antipyretic and anti-inflammatory drug

M. Bindhammer 04/18/2017 at 18:495 Comments

Based on my research on the former log I started to develop an antipyretic and anti-inflammatory drug which works within 10 seconds by absorption through the skin. I will call it Ibupromt.

I pestled three 400 mg Ibuprofen pills, put it in an Erlenmeyer flask, added 40 ml dichloromethane and let it set for at least one hour.

Then I filtered the solution off by adding piece wise another 40 ml dichloromethane to the filter cake. Re-crystallization of solids in the petri dish started immediately as dichloromethane is highly volatile.

After all dichloromethane evaporated I measured the weight of the filter cake:Assuming all ibuprofen were dissolved by the dichloromethane, I should have now 1895 mg containing 1200 mg ibuprofen left in the re-crystallized filtered solution, means I must get rid of 695 mg of other in dichloromethane dissoluble ingredients.

I dried the re-crystallized stuff for 5 hours at 70° C on a lab hot plate.As mentioned ibuprofen is practically insoluble in water. I put the re-crystallized and dried filtrate in a beaker, added 100 ml distilled water and heated it up to 70° C and stirred it for 2 hours, to remove any water-soluble remaining ingredients.

Then I filtered it off again.

Afterwards I dried the filter cake at 70° C for 5 hours and measured the weight again. I was expecting around 1200 mg, but the yield was only 700 mg. I doubt one pill really contains 400 mg ibuprofen, but I do not have time to prove that the pharmaceutical industry is cheating. The public trade supervision will do that for me.

Next I dissolved the 700 mg ibuprofen in 5 ml of 50° C warm DMSO. This happens quick, within a few seconds.

Then I filtered the solution again off directly into a brown medicine bottle. I used a quite warm place (nearby the radiator in my bathroom with floor heating; melting point of pure DMSO is approx. 19° C).

Finally I labeled the medicine bottle accordingly.


Discussions

M. Bindhammer wrote 2 days ago point

Hi David, will check this evening. Thank you!

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David H Haffner Sr wrote 5 days ago point

The method will still work my friend, I've used it to dissolve Aspirin tablets to isolate the Salicylic acid. You have to use a pill crusher (a good one that uses a circular pivot to grind it to a very fine powder, the finer the powder, the easier to dissolve in a non-polar solvent.

Your going to make a solution based upon a % of water and solvent (your choice,) for example the boiling point of Ethanol is 172.83 (f) Ibuprofen's has a melting point of ; 75 to 78 °C (167 to 172 °F) 

You are correct about synthesis, just wanted to recommend some alternatives that might work for a purier sample without any residue that may seep into your skin :)

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David H Haffner Sr wrote 5 days ago point

Hey Markus, my man, there is an easier way to do this. Fractional distillation, a little bit more involved set up but worth the investment and time, as long as >95% of the substance you want to separate out is the major component this is the way to go.

I have this method set up were I live, it involves separating each component by its respective boiling point, the set up for fractional distillation is essentially the same as simple distillation except that a fractionating column is placed between the boiling flask and the condenser.

The fractionating column is usually filled with a packing material such as glass, steel wool, or plastic beads. The packing material increases the surface area and  improves the separation between the liquids being distilled. The reason that fractional distillation gives better separation between the liquids is because the packing material in the fractionating column provide "theoretical plates" on which the refluxing liquid can condense, re-evaporate, and condense again, essentially distilling the compound over and over. 

The more volatile liquids will tend to push towards the top of the fractionating column, while lower boiling liquids will stay towards the bottom, giving a better separation between the liquids. Of course, the more theoretical plates that you add to a column (the more surfaces or beads), the longer the distillation will take (typically), and the more energy required to keep reevaporating liquid in the fractionating column.

This is a much more precise and cleaner way to do this procedure, especially since you are experimenting on yourself :)

Here is a good place to start with a simple set up:

http://en.wikipedia.org/wiki/Fractional_distillation

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M. Bindhammer wrote 5 days ago point

Hi David, thanks. I know this. But I want to separate ibuprofen. How can this be done by fractional distillation? It's a solid substance. And all side ingredients are solids too. The cleanest way in my opinion would be a synthesis of ibuprofen, but it's not as easy as acetylsalicylic acid. I have learned this way in chemistry to isolate a solid substance by its dissolubility and maybe precipitation. Anyhow, this is only a small fraction of the initial idea. The pump breakout board is out to the pcb fab. I should be able soon to present some interesting results :) Good luck with your own project and keep in touch!

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David H Haffner Sr wrote 2 days ago point

Hello Markus, hey my man, I found the perfect video that shows an extraction process that actually works and gives a 94% product yield :) Please check it out and get back with me and let me know what you thought about it.

http://www.youtube.com/watch?v=ZRvMM_TPuoU

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