Found some time this evening to hook up the Mega-One-8-One for testing. The Mega-One-8-One is a gate level accurate replicate of the classic 74181 Arithmetic-Logic Unit(ALU) for educational purposes. With the exception of one LED not being soldered down properly, everything is working! I ran through a series of tests and everything looks great so far! I tried to make the board layout very similar to the block diagrams that are often distributed with the datasheet for the 74181, but I am noticing that the "hook-up" using this layout is not very easy. I am going to have to think about the connectivity for the next revision.
Feedback is greatly appreciated!