The set up of the Curie went very smooth. Drivers automatically installed using Windows 10. I also did not have issues adding the Arduino 101 to the Arduino IDE via the boards manager in the IDE. With all that luck, I was hoping to not have to restart the Arduino IDE or my CPU before uploading a sketch. That was not the case. Before doing anything I checked the Device Manager in Windows and saw that the Curie was only showing as a USB Serial Device on COM22. Rebooting my computer provided the recognition of the Curie that I was looking for as it now showed up as the Arduino 101 in the Device Manager.
If all else fails...restart everything